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KMID : 0382619870070020935
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Hanyang Journal of Medicine
1987 Volume.7 No. 2 p.935 ~ p.943
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Effects of Bleomycin Hydrochloride on Alkaline Phosphatase in Mouse Liver
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Abstract
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Bleomycin hydrochloride isolated from the Streptomyces veticillus has been widely used as an anticancer drug. It exhibits specific antineoplastic activity against squamous epithelial carcinomas of the skin. Bleomycin causes inhibition of DNA and protein synthesis by incorporating bithiazole group of the drug into DNA.
The author undetook the present study to investigate the effect of bleomycin on the alkaline phosphatase activity in the mouse liver. The experimental animals were sacrificed at 6, 12, 24, and 48 hours after administration of 150 mg/kg of bleomycin. The activity of alkaline phosphatase was observed by Gomori´s method for histochemical study.
The results were as follows.
The activity of alkaline phosphatase was decreased in the entire hepatic lobule of the 12 hours belomycin treated group and recovered in the 24 hours bleomycin treated group.
Consequentoy it is suggested that bleomycin has the cytotoxic effect on the hepatocytes.
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